I'm eternally surprised when I realize that there are people out there who know nothing about MKULTRA...
Here's a quick summary from wikipedia...
Project MKULTRA, or MK-ULTRA, was the code name for a CIA mind-control research program that began in 1950, run by the Office of Scientific Intelligence.[1][2][3]. There is much published evidence that the project involved the use of many types of drugs, as well as other methodology, to manipulate individual mental states and to alter brain function.[4]